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NEMO PCC Meeting
 
The NEMO PCC Meeting took place on the 25th and 26th of April and was held in Hotel Bloom!  Brussels – Belgium

The NEMO PCC Meeting took place on the 25th and 26th of April and was held in Hotel Bloom!  Brussels – Belgium. The meeting was attended  by the scientific officer Alexandru Sorin Costescu, from the European Union Commisson, who gave the consortium helpful recommendations for the continuation of the project.  He gave a presentation on Horizon 2020 and explained to the consortium some of the future developments in European funding for research in paediatric medicine. The meeting involved a lot of discussions and an exciting exchange of ideas. The day ended with a working dinner in the European Quartier of Brussels. Please note for future Project Meetings Social activities such as guided city tours etc. are no longer eligible for direct EC funding; therefore they need to be covered individually by each participant. 


Side Articles
Publications
Here, in no particular order, are some more publications from the busy NEMO group...

Measuring neurodevelopmental outcome in neonatal trials: a continuing and increasing challenge.
Marlow N.
Arch Dis Child Fetal Neonatal Ed. 2013 Jul 9.

Monitoring neonatal seizures. 
Boylan GB, Stevenson NJ, Vanhatalo S.
Semin Fetal Neonatal Med. 2013 Aug;18(4):202-8. Epub 2013 May 24.

Functional Bimodality in the Brain Networks of Preterm and Term Human Newborns. 
Omidvarnia A, Fransson P, Metsäranta M, Vanhatalo S.
Cereb Cortex. 2013 May 5.

Adverse effects following lidocaine treatment are limited with current dosing regimens. 
Lundqvist M, Agren J, Hellström-Westas L, Flink R, Wickström R.
Acta Paediatr. 2013 Aug 12.

Placental Pathology in Full-Term Infants with Hypoxic-Ischemic Neonatal Encephalopathy and Association with Magnetic Resonance Imaging Pattern of Brain Injury. 
Harteman JC, Nikkels PG, Benders MJ, Kwee A, Groenendaal F, de Vries LS.
J Pediatr. 2013 Jul 24.

 (1)H NMR derived metabolomic profile of neonatal asphyxia in umbilical cord serum: implications for hypoxic ischemic encephalopathy. 
Reinke SN, Walsh BH, Boylan GB, Sykes BD, Kenny LC, Murray DM, Broadhurst DI.
J Proteome Res. 2013 Sep 6;12(9):4230-9.

Anticonvulsant effect of xenon on neonatal asphyxial seizures. 
Azzopardi D, Robertson NJ, Kapetanakis A, Griffiths J, Rennie JM, Mathieson SR, Edwards AD.
Arch Dis Child Fetal Neonatal Ed. 2013 Sep;98(5):F437-F439.

Apgar score of 0 at 5 minutes and neonatal seizures or serious neurologic dysfunction in relation to birth setting. 
Grünebaum A, McCullough LB, Sapra KJ, Brent RL, Levene MI, Arabin B, Chervenak FA.
Am J Obstet Gynecol. 2013 Jun 19.

Introduction of hypothermia for neonates with perinatal asphyxia in the Netherlands and Flanders. 
Groenendaal F, Casaer A, Dijkman KP, Gavilanes AW, de Haan TR, ter Horst HJ, Laroche S, Naulaers G, Rijken M, van Straaten HL, Steiner K, Swarte RM, Zecic A, Zonnenberg IA. Neonatology. 2013;104(1):15-21.

Investigations for neonatal seizures. 
Hallberg B, Blennow M.
Semin Fetal Neonatal Med. 2013 Aug;18(4):196-201.

Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden. 
Serenius F, Källén K, Blennow M, Ewald U, Fellman V, Holmström G, Lindberg E, Lundqvist P, Maršál K, Norman M, Olhager E, Stigson L, Stjernqvist K, Vollmer B, Strömberg B; EXPRESS Group.
JAMA. 2013 May 1;309(17):1810-20.

Neonatal seizures: the journey so far. 
Boylan GB, Pressler RM.
Semin Fetal Neonatal Med. 2013 Aug;18(4):173-4.

Experimental designs for small randomised clinical trials: an algorithm for choice. 
Cornu C, Kassai B, Fisch R, Chiron C, Alberti C, Guerrini R, Rosati A, Pons G, Tiddens H, Chabaud S, Caudri D, Ballot C, Kurbatova P, Castellan AC, Bajard A, Nony P; CRESim & Epi-CRESim Project Groups, Aarons L, Bajard A, Ballot C, Bertrand Y, Bretz F, Caudri D, Castellan C, Chabaud S, Cornu C, Dufour F, Dunger-Baldauf C, Dupont JM, Fisch R, Guerrini R, Jullien V, Kassaï B, Nony P, Ogungbenro K, Pérol D, Pons G, Tiddens H, Rosati A, Alberti C, Chiron C, Kurbatova P, Nabbout R.
Orphanet J Rare Dis. 2013 Mar 25;8:48.

Neuropaediatric and neuroarchaeology: understanding development to correct brain disorders. 
Ben-Ari Y.
Acta Paediatr. 2013 Apr;102(4):331-4..

 Transition and transfer from pediatric to adult health care in epilepsy: A families' survey on Dravet syndrome. 
Kuchenbuch M, Chemaly N, Chiron C, Dulac O, Nabbout R.
Epilepsy Behav. 2013 Oct;29(1):161-5. 


Information
PGB meeting, Paris
 

The Project Governing Board meeting this year will take place in France at Fondation Royaumont,   F-95270 Asnières-sur-Oise just outside Paris between the 23th and 24th September 2013. 


The Project Governing Board meeting this year will take place in France at Fondation Royaumont,  F-95270 Asnières-sur-Oise, just outside Paris between the 23th and 24th September 2013. 

The first day is reserved for subgroup meetings and workshops. On the 2nd day we will concentrate on the work packages and on future developments including a review of the exploitation strategies for NEMO. The final decision on the dates and locations of the future NEMO meeting in 2014 will also be made at this meeting, so calenders at the ready 

Royaumont Abbey was built in the thirteenth century by Saint Louis. Set in a protected environment, the abbey has stood still in the middle of ponds and forests. Its cloister and refectory are among the most notable to date while the park and gardens are ideal for a stroll. Since 2004, a medieval style garden "Garden of the nine squares" has been open to the public and every three years, a new collection of plants is welcomed to the gardens. Since June 2010, the spotlight has been on "magic" plants.

Also a reminder that the next reporting period for NEMO is from October 2012 until March 2013. Deadline for submission of the scientific and financial report is end of May 2013. The final report is due 60 days after the end of the project, which is officially the 30th of September 2014 and will include the period from April 2013 until the end of the project. Periodic reports have been submitted so far for the periods: October 2009-March 2011 and April 2011-September 2012. Submitting reports is very important for the project both to show the progress of the project but also perhaps more importantly the progressthen determines the next payment.


Feature Story
Welcome
 

Welcome to the fourth issue of the NEMO newsletter. Since the last meeting in Brussels in April 2013 a lot has changed in the NEMO project, both in personnel and direction. As part of the move away from bumetanide we are drafting the end of trial report for NEMO-1 and it is hoped that this will be completed shortly We would also like to congratulate Dr Johanneke Harteman who was recently conferred with her PhD. Johanneke will be missed from the NEMO team and we wish her luck in her new post. We welcome on board Ms Louise Jones to the NEMO trial management team..

We would like to mention all our colleagues who contributed to the recent. Neonatal Seizure Issue of “Seminars in Fetal and Neonatal Medicine”. Thank you again for all the hard work and often late nights.

Best wishes

Ronit and Geraldine


News and Views
Change in personnel
 
With this issue we say a final good bye from the NEMO project to Havinder Hara and welcome on board Louise Jones. Louise will be based in University College London and will helping with the trial co-ordination.

With this issue we say a final good bye from the NEMO project to Havinder Hara and welcome on board Louise Jones. Louise will be based in University College London and will helping with the trial co-ordination. Louise has worked as a Medical Secretary/PA for over 25 years.  She worked within the NHS - working for Orthopaedic Surgeons, Paediatrician’s & Neurosurgeon’s. 

From 1992-1996 she worked as PA to the Managing Director of a Pharmaceutical Company.  For the past 11 years she has worked as PA to Professor Helen Cross and Professor Brian Neville at Young Epilepsy, an Epilepsy Charity based in Lingfield, Surrey, which has connections to Great Ormond Street Hospital.  She continues to combine this role 2 days a week whilst also working for Dr Pressler 2 days per week. 

 Louise is married with 2 sons aged 16 and 14.


Research Centre Opened
 
Irish Centre for Fetal and Neonatal Translational Research (INFANT) was offically launched in Cork University Maternity Hospital on the 20th September 2013. Funded by Science Foundation Ireland (SFI) this centre under the directorship of Profs Geraldine Boylan and Louise Kenny will be the first centre for fetal and neonatal research in Ireland.

Irish Centre for Fetal and Neonatal Translational Research (INFANT) was offically launched in Cork University Maternity Hospital on the 20th September 2013. Funded by Science Foundation Ireland (SFI) this centre under the directorship of Profs Geraldine Boylan and Louise Kenny will be the first centre for fetal and neonatal research in Ireland. NEMO is very well representated in INFANT as Dr Deirdre Murray is an INFANT PI and Dr Ronit Pressler and Dr Janet Rennie are named INFANT collaborators. 

The INFANT team, a group of doctors, scientists and engineers, are developing screening and diagnostic tests and methods of monitoring both pregnancy and newborns, identifying risk and enabling early treatment and intervention. Discoveries will quickly update clinical practice and the diagnosis of disease worldwide for the most common and serious complications in pregnancy and newborn babies. 

INFANT addresses a lack of predictive and diagnostic tests in perinatal care, to develop effective screening tests and facilitate novel treatments for the most common complications of pregnancy and the most significant problems for newborn babies in intensive care. Next generation devices will be created to allow both point-of-care and remote healthcare monitoring and diagnostics. INFANT is working closely with industry partners to ease the burden of perinatal health complications and deliver enormous social and economic impact.

INFANT website 


Meet The Team
Neuroscience Ireland Annual Meeting
On the 12th of September 2013 Geraldine Boylan and David Henshall hosted the  " The Developing Brain" morning session
On the 12th of September 2013 Geraldine Boylan and David Henshall hosted the  " The Developing Brain" morning session, at the combined meeting of Neuroscience Ireland and Irish Area Section Biochemical Society. The meeting was held on the 12th – 13th of September 2013 and was dedicated to “Brain Disorders Across the Lifespan: Translational Neuroscience From Molecule to Man“. The Developing Brain session featured Yehezke Ben-Ari, Peirre Gressen and Susan Vannucci as speakers and was very well received by the audience. The full program can be found here.
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